GST-A20(1-365)
Deubiquitinating enzymes (DUBs) are proteases that posses the ability to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. A20 downregulates the NF-κB pathway and proinflammatory gene expression in cells such as macrophages. The N-terminal domain of A20 contains the DUB activity.
Product Name:
GST-A20(1-365)
>Also Known As:
TNFAIP3; OTUD7C; TNFA1P2
>Catalog No.:
H3210
>Size:
25 µg
>Molecular Weight:
89.6 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
~95% by SDS-PAGE, see datasheet for gel image
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
NM_006290
>Image(s):
N/A
>Shipping Method:
Dry ice shipping
>References:
1. Opipari AW Jr, et al. (1990) J Biol Chem 265(25), 14705 – 14708.
2. Boone DL, et al. (2004) Nat Immunol 5(10), 1052 – 1060. GSK126 18469041
