One of the known mechanisms of PC6 action in regulating endometrial epithelial cell receptivity is through the cleavage of pro-integrin-aV into its functional heavy and light chains. To further establish…
effects was instrumental in advancing the drug discovery effort for the identification of DGAT1 small molecule inhibitors with minimal impact in the skin. Furthermore molecular markers in mouse skin were…
Analyzing this sequence in reference to the other unsuccessful peptide designs from Run 3 and the successful designs from Run 4, a consistent mutation of S28N is observed for successful…
An AlphaLISA assay adaptable to HTS in 384 well plates was designed to measure the TG2-FN interaction. The assay measures the interaction between His6-TG2 bound to Ni-chelated acceptor beads and…
Furthermore, we did not find evidence for 4EBP1 phosphorylation that is resistant to asTORi, a phenomenon observed in KRAS-mutant colon cancer cells. An interesting observation from these western blots was…