One study has documented increased PPI use in the outpatient setting but to our knowledge, no studies have examined very recent national trends in PPI use in the U.S. outpatient setting, the characteristics of patients on PPIs, the characteristics of physicians who 871361-88-5 prescribe PPIs, and trends in indications for their use. Knowledge of these trends and characteristics may inform patients, physicians, payers, and policymakers who want to receive or deliver high quality, high value care. We used data from two national surveys of visits to ambulatory physicians to describe recent trends in the use of PPIs in the ambulatory setting. We explored potential reasons for these trends by looking at changes in the prevalence of newly prescribed PPIs, changes in histamine blocker use, and changes in the prevalence of indications for their use. The first stage is based on geographic location, the second stage identifies offices in each geographic location, and the third stage samples visits within each office. The visits sampled take place during a one week period that is randomly assigned for each practice. Between 20% and 100% of the visits that week are sampled depending on the size of the practice. The NCHS weighs each visit so that the data can be used for national estimates. Each visit weight accounts for selection probability, adjusts for nonresponse, and accounts for other factors so that the national estimates properly reflect the scope of ambulatory visits in the U.S. Physicians in the fields of anesthesiology, radiology, and pathology are excluded from the survey. Physicians who participate in the survey cannot participate again for at least three years. There has been no change in the sampling design for our study period. The surveys collect physician and office demographics, patient demographics, and visit-specific clinical information. For each visit, the surveys record up to three diagnoses based on the International Classification of Diseases, Ninth Revision, Clinical Modification and up to three reasons for visits which are based on the patients complaints or symptoms. The surveys also record up to eight medications that the patient is currently taking or that are prescribed at the visit. The survey specifically asks for both prescribed and over-the-counter medications. The information from each visit is recorded on a standardized survey form by the physician, office staff representative. Each visit is HOE-239 weighted so that national estimates can be calculated. The study was approved by the institutional review board of Weill Cornell Medical College.
