GST-NEMO (L329P)
NF-κB essential modulator (NEMO) is a regulatory subunit within IκB kinase (IKK). IKK is also composed of two unrelated catalytic subunits called IKKα and IKKβ. NEMO is additionally referred to as IKKγ, IKKAP1, or FIP-3. IKK is responsible for activating the transcription factor, NF-κB, which is involved in immune response. NEMO prefers to bind K63-linked or linear polyubiquitin chains.
The L329P substitution abolishes NEMO interacts with linear polyUb chains and long K63 polyubiquitin chains.
Product Name:
GST-NEMO (L329P)
>Also Known As:
IKBKG; IP; IP1; IP2; FIP3; IPD2; NEMO; FIP-3; Fip3p; AMCBX1; ZC2HC9; IKK-gamma
>Catalog No.:
I1510
>Size:
25 µg
>Molecular Weight:
48.2 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
~80% by SDS-PAGE, see datasheet for gel image
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
NM_001099857
>Image(s):
(Click image to enlarge)
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified GST-NEMO (L329P) |
>Shipping Method:
Dry ice shipping
>References:
1. Rothwarf DM, et al. (1998) Nature 395, 297 – 300.
2. Yamaoka S, et al. (1998) Cell 93, 1231 – 1240.
3. Ghosh S, Karin M (2002) Cell 109 Suppl, S81 – 96. Pimavanserin 18483244
