MK-2206 dihydrochloride
MK-2206 dihydrochloride is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins.
Product Name:
MK-2206 dihydrochloride
>Also Known As:
MK-2206 2HCl, 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one
>Catalog No.:
F6160
>Size:
5 mg
>CAS:
1032350-13-2
>Formula:
C25H21N5O.2HCl
>Molecular Weight:
480.39 Da
>Form:
Lyophilized powder
>Quality Assurance:
>98% by HPLC and NMR
>Source:
Synthetic
>Storage:
Eligible for room temperature shipping. Store at -80°C upon receiving
>PDF Data Sheet:
Download PDF datasheet
>Image(s):
N/A
>Shipping Method:
Room temperature shipping
>References:
Yan L., et al. (2009) Abstract Number: DDT01-1. Romidepsin 18480410
