PAC-1
PAC-1 is a caspase-3 activator. It promotes cleavage of procaspase-3 to produce caspase-3 (EC50 = 0.33 μM). It also converts procaspase-7 to caspase-7 at higher dose (EC50 = 4.5 μM). By induction of caspase-3 and 7, PAC-1 can induce apoptosis in both cancerous cells and non-cancerous cells, but more efficiently for cancerous cells.
Product Name:
PAC-1
>Also Known As:
N/A
>Catalog No.:
F7130
>Size:
5 mg
>CAS:
315183-21-2
>Formula:
C23H28N4O2
>Molecular Weight:
392.49 Da
>Form:
Lyophilized powder
>Quality Assurance:
>98% by HPLC and NMR
>Source:
Synthetic
>Storage:
Eligible for room temperature shipping. Store at 2-8°C upon receiving
>PDF Data Sheet:
Download PDF datasheet
>Image(s):
N/A
>Shipping Method:
Room temperature shipping
>References:
1. Putt et al. (2006) Nat.Chem.Biol. 2 543.
2. Peterson et al. (2009) J.Med.Chem. 52 5721. Tipifarnib 18481291
