Torin-1
Torin 1-is a cell permeable highly potent, selective and ATP-competitive mTOR inhibitor of the mammalian target of rapamycin (mTOR) kinase. Torin-1 exhibits over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, as well as 450 other protein kinases. Torin-1 has been found to impair cell growth and proliferation through a mechanism involving mTORC1 inhibition other than mTORC2 inhibition, in which the rapamycin-resistant functions of mTORC1 is suppressed.
Product Name:
Torin-1
>Also Known As:
1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
>Catalog No.:
F6100
>Size:
5 mg
>Molecular Weight:
607.62 Da
>Species:
N/A
>Source:
Synthetic
>Stock:
Powder
>Concentration:
N/A
>Quality Assurance:
>99% by HPLC and NMR
>Storage:
Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
>PDF Data Sheet:
PDF Datasheet
>NCBI RefSeq:
N/A
>Image(s):
N/A
>Shipping Method:
Room temperature shipping
>References:
1. Guertin DA, et al. (2009) Sci.Signal. 2(67):pe24
2. Thoreen CC, et al. (2009) J.Biol.Chem. 284(12):8023-32
3. Liu Q, et al. (2010) J.Med.Chem. 53(19):7146-55 UNC0642 18480170
