Idarubicin HCl
Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. Idarubicin is developed in an attempt to reduce the cardiotoxicity and enhance the therapeutic efficacy of the parent compound. Idarubicin HCl is an inhibitor of Topo II α and an apoptosis inducer. Idarubicin HCL was used at 0.1 nM – 10 nM in various cell-based in vitro assays.
Product Name:
Idarubicin HCl
>Also Known As:
4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl
>Catalog No.:
F8100
>Size:
5 mg
>Molecular Weight:
533.95 Da
>Species:
N/A
>Source:
Synthetic
>Stock:
Powder
>Concentration:
N/A
>Quality Assurance:
>99% by HPLC and NMR
>Storage:
Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
>PDF Data Sheet:
PDF Datasheet
>NCBI RefSeq:
N/A
>Image(s):
N/A
>Shipping Method:
Room temperature shipping
>References:
1. Fukushima T, et al. (1993). Int. J. Hematol. 57: 121-130.
2. Belaud-Rotureau MA, et al. (2000). Leukemia. 14: 1266-1275.
3. Orlandi P, et al. (2005) J Chemother. 17(6): 663-667.
4. Colburn DE, et al. (2004) Hematology. 9(3): 217-221. A-1155463 18481785
