Doxorubicin HCl
Doxorubicin is an anthracycline antitumor antibiotic that Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Doxorubicin binds covalently to DNA and inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1.
Product Name:
Doxorubicin HCl
>Also Known As:
10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
>Catalog No.:
F8110
>Size:
5 mg
>Molecular Weight:
579.99 Da
>Species:
N/A
>Source:
Synthetic
>Stock:
Powder
>Concentration:
N/A
>Quality Assurance:
>99% by HPLC and NMR
>Storage:
Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
>PDF Data Sheet:
PDF Datasheet
>NCBI RefSeq:
N/A
>Image(s):
N/A
>Shipping Method:
Room temperature shipping
>References:
1. Taatjes DJ, et al (1996) J. Med. Chem. 39: 4135-4138.
2. Pourquier P, et al. (1998) Biochem. Pharmacol. 55: 1963-1971.
3. Zeman SM, et al. (1998) Proc. Natl. Acad. Sci. U.S.A. 95: 11561-11565.
4. Sun W, et al. (2009 ) Cancer Res. 69(10): 4294-4300.
5. Granados-Principal S, et al. (2010) Food Chem Toxicol 48(6): 1425-1438. Tenofovir (Disoproxil Fumarate) 18481926
